The RNAs and Proteins of dsRNA Viruses

 

Edited by Peter. P. C. Mertens, Houssam Attoui and Dennis H. Bamford

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[The ds RNA genome segments and proteins of simian rotavirus A / SA11 (SiRV-A/SA11) genus Rotavirus ]

 

 

Coding assignments and virion locations of rotavirus proteins 

and 3D structure of the rotavirus particle. (available as a Word file)

 

Figure supplied by Eric Mossel , Mary Estes and Frank Ramig

 

Genome Segments: Shows PAGE separation of the 11 segments of the rotavirus SA11 genome.

Encoded proteins: Shows the PAGE separation of the intracellular proteins synthesized by SA11 and the genome segment in which they are encoded. Six structural (VP) and six nonstructural (NSP) proteins are synthesized in the infected cell. Note that NSP6 runs far below NSP5 and is not shown on the gel presented here.

Viron Schematic: Shows the locations of the various structural proteins within the rotavirus virion. Note the arrangement of the proteins into 3 concentric capsid layers, and the location of the VP1/VP3 complexes at the 5-fold verticies of the icosahedral structure.

Reconstruction: A 3D reconstruction of the SA11 virion (23Å resolution) with the genome computationally removed. The color scheme is the same as the schematic, to indicate locations of the various proteins. (Courtesy of J. Lawton and B.V.V. Prasad).

 

Table supplied by Eric Mossel , Mary Estes and Frank Ramig

 
 

 

(The RNAs and Proteins  of dsRNA Viruses:  Edited by Peter. P. C. Mertens, Houssam Attoui and Dennis H. Bamford)